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According to NORD, the National Organisation for Rare Disorders, there are five types of Stiff Person Syndrome:

1) Classic SPS

2) Focal SPS

3) Jerking SPS

4) Progressive Encephalomyelitis with Rigidity and Myoclonus (PERM)

5) Paraneoplastic-Related SPS

Click on the links below to take you to various SPS pages from the internet or our file library. They are strictly for information only and do not represent advice or recommendations by the UK and Ireland SPS Support Group and Charity. If you have more links you believe would be of interest to the community, please submit for consideration to:

Patient Histories/Case Studies

NICE logo.png

NICE is the UK's National Health Service (NHS) National Institute for Health and Care Excellence. This link takes you direct to NICE's website


This US government site brings together SPS and SPS-related links across the internet. The usagov link (LEFT) goes directly to the site section about SPS and is pre-loaded with a search for anything Stiff Person Syndrome. In the first 30 pages, there are 600 randomly arranged links, not all of which are SPS related/connected. Many, but not all, links are the same listed here on our website. However, refined searches can be carried out to reveal specific information/results.

A rarity among the rare: Psychiatric manifestations in a young woman with SPS (2022)

Exchanging plasma in patient’s blood can cure stiff muscles (2022)

A rare case of SPS with pulmonary complications (2022)

Glycine receptor autoantibodies impair receptor function and induce motor dysfunction (2020)

The dilemma, conversion disorder or SPS, a case report (2021)

Progressive encephalomyelitis with rigidity and myoclonus (2020)

Breast cancer-associated paraneoplastic SPS: anastrozole monotherapy insufficient for symptom improvement (2021)

GAD65 autoimmunity after treatment with nivolumab: a multifocal presentation (2021)

Improvement of SPS symptoms in pregnancy (2020)

Retinal pathology occurs in SPS (2020)

SPS painful spasms during childhood (2021)

SPS associated with compartment syndrome (2019)

Disability in patients with SPS may progress faster than thought (2018)

Clinical and immunologic investigations in patients with SPS spectrum disorder (2016)

Brain and muscle metabolic changes by FDG-PET in SPS spectrum disorders (2021)

Cerebellar ataxia followed by SPS in a patient with anti-GAD antibodies (2020)

SPS masquerading as multiple sclerosis (2017)

Not always anxiety - a tough diagnosis of SPS (2017)

Advances and review on treatment of SPS in adults and pediatric patients (2015)

Trismus as a presenting symptom in a case of PERM (2019)

Quantitative clinical and autoimmune assessments in SPS: evidence for a progressive disorder (2019)

Anti-glutamic acid decarboxylase-65 antibody positive SPS presenting Initially as acute peripheral vestibulopathy, leading to delayed diagnosis after multiple hospitalisations (2019)

Is SPS benefitted by physical therapy intervention? (2019)

Evaluation of treatment outcomes in patients with SPS with rituximab v standard of care (2017)

47-year-old female with muscular rigidity new-onset diabetes and hypothyroidism (2013)

Pregnancy and SPS (2012)

SPS: avoiding misdiagnosis (2007)

Surviving SPS (2011)

Cognitive decline in a patient with anti-glutamic acid decarboxylase autoimmunity (2011)

Stiff eyes in SPS (2009)

Treatment of SPS with chronic plasmapheresis (2013)

SPS presenting with headache (2004)

Efficacy of therapeutic plasma exchange for treatment of SPS (2014)

SPS with sudden onset of shortness of breath and difficulty moving the right arm (2010)

SPS: Results of interviews and psychological testing (1998)

Neuropsychological assessment of phobias in SPS (2005)

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Patient with reflex myoclonus and muscle rigidity:'jerking stiff-man syndrome" (1980)

Stiffness, spasticity, or both (2002)

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Motor cortex excitability in SPS (2000)

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GAD65 positive autoimmune limbic encephalitis: Case report (2012)

Quality of life in SPS (2002)

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Total intravenous anesthesia (TIVA) for SPS (2012)

SPS without DM1 (2010)

Effects of immunotherapy on motor cortex excitability in SPS (2009)

CD4+ T-cells specific for (GAD65) and proinsulin with SPS but not IDDM (2011)

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