According to NORD, the National Organisation for Rare Disorders, there are five types of Stiff Person Syndrome:

1) Classic SPS

2) Focal SPS

3) Jerking SPS

4) Progressive Encephalomyelitis with Rigidity and Myoclonus (PERM)

5) Paraneoplastic-Related SPS

Click on the links below to take you to various SPS pages from the internet. They are strictly for information only and do not represent advice or recommendations by the UK and Ireland SPS Support Group and Charity. If you have more links you believe would be of interest to the community, please submit for consideration to:

Patient Histories/Case Studies

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NICE is the UK's National Health Service (NHS) National Institute for Health and Care Excellence. This link takes you direct to NICE's website


This US government site brings together SPS and SPS-related links across the internet. The usagov link (LEFT) goes directly to the site section about SPS and is pre-loaded with a search for anything Stiff Person Syndrome. In the first 30 pages, there are 600 randomly arranged links, not all of which are SPS related/connected. Many, but not all, links are the same listed here on our website. However, refined searches can be carried out to reveal specific information/results.

47-year-old female with muscular rigidity new-onset diabetes and hypothyroidism (2013)

Pregnancy and SPS (2012)

SPS: avoiding misdiagnosis (2007)

Surviving SPS (2011)

Cognitive decline in a patient with anti-glutamic acid decarboxylase autoimmunity (2011)

Stiff eyes in SPS (2009)

Treatment of SPS with chronic plasmapheresis (2013)

SPS presenting with headache (2004)

Efficacy of therapeutic plasma exchange for treatment of SPS (2014)

SPS with sudden onset of shortness of breath and difficulty moving the right arm (2010)

SPS: Results of interviews and psychological testing (1998)

Neuropsychological assessment of phobias in SPS (2005)

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Patient with reflex myoclonus and muscle rigidity:'jerking stiff-man syndrome" (1980)

Stiffness, spasticity, or both (2002)

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Motor cortex excitability in SPS (2000)

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GAD65 positive autoimmune limbic encephalitis: Case report (2012)

Quality of life in SPS (2002)

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Total intravenous anesthesia (TIVA) for SPS (2012)

SPS without DM1 (2010)

Effects of immunotherapy on motor cortex excitability in SPS (2009)

CD4+ T-cells specific for (GAD65) and proinsulin with SPS but not IDDM (2011)

Stiff Person Syndrome Associated with Compartment Syndrome (2019)

Improvement of SPS symptoms in pregnancy (2020)

Progressive encephalomyelitis with rigidity and myoclonus (2020)

Retinal pathology occurs in SPS (2020)

Not always anxiety - a tough diagnosis of SPS (2017)

Quantitative clinical and autoimmune assessments in SPS: evidence for a progressive disorder (2019)

Evaluation of treatment outcomes in patients with SPS with rituximab v standard of care (2017)

SPS masquerading as multiple sclerosis (2017)

Clinical and immunologic investigations in patients with SPS spectrum disorder (2016)

Disability in patients with SPS may progress faster than thought (2018)

SPS and epilepsy: duality of GAD 65 being associated with both SPS and the pathogenesis in adult onset epilepsy (2017)

Cerebellar Ataxia followed by SPS in a patient with anti-GAD antibodies (2020)

Advances and review on treatment of SPS in adults and pediatric patients (2015)

Anti-glutamic acid decarboxylase-65 antibody positive SPS presenting Initially as acute peripheral vestibulopathy, leading to delayed diagnosis after multiple hospitalisations (2019)

Trismus as a presenting symptom in a case of PERM (2019)

Is SPS benefitted by physical therapy intervention? (2019)

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Copyright © 2018 Stiff Man Syndrome Charity. All rights reserved

UK Telephone: 01482 868881  

Stiff Man Syndrome UK and Ireland Support Group and Charity: Founded in 1998 by Liz Blows

Stiff Man Syndrome Support Group and Charity: Liz Blows (Chair), 75 Normandy Avenue, Beverley, East Yorkshire, HU17 8PF
Stiff Man Syndrome Support Group and Charity is not-for-profit
Charity Number: 1099206

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