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According to NORD, the National Organisation for Rare Disorders, there are five types of Stiff Person Syndrome:

1) Classic SPS

2) Focal SPS

3) Jerking SPS

4) Progressive Encephalomyelitis with Rigidity and Myoclonus (PERM)

5) Paraneoplastic-Related SPS

Click on the links below to take you to various SPS pages from the internet or our file library. They are strictly for information only and do not represent advice or recommendations by the UK and Ireland SPS Support Group and Charity. If you have more links you believe would be of interest to the community, please submit for consideration to:

Available or Suggested Treatments

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NICE is the UK's National Health Service (NHS) National Institute for Health and Care Excellence. This link takes you direct to NICE's website


This US government site brings together SPS and SPS-related links across the internet. The usagov link (LEFT) goes directly to the site section about SPS and is pre-loaded with a search for anything Stiff Person Syndrome. In the first 30 pages, there are 600 randomly arranged links, not all of which are SPS related/connected. Many, but not all, links are the same listed here on our website. However, refined searches can be carried out to reveal specific information/results.

Preliminary study: Blood treatment is safe, may help treat SPS (2022)

Plasmapheresis may help treatment of patients with SPS (2022)

Update on intravenous Immunoglobulin in neurology: modulating neuro-autoimmunity, evolving factors on efficacy and dosing and challenges on stopping chronic IVIg herapy (2021)

Unanticipated Improvement of SPS after severe COVID-19 (2021)

SPS spectrum disorders; more than meets the eye *2022)

SPS can now be treated: Study (2022)

Preliminary Study: Blood treatment is safe, may help treat SPS (2022)

Stiff-Person-Syndrom: muskelkrämpfe in beinen und rücken (2021)

Is SPS benefited by physical therapy intervention? (2019)

Intravenous immunogloblin offers new treatment opportunities for neurological diseases (2021)

Recent advances and review on treatment of SPS in adults and pediatric patients (2015)

Brain and muscle metabolic changes by FDG-PET in SPS Spectrum Disorders (2021)

Limited benefits halt enrollment in hematopoietic stem cell transplantation trial for SPS (2020)

Surgical treatment for toe deformities in SPS (2020)

Clinicopathologic features of amphiphysin-IgG autoimmune neuropathy (first reported in SPS with breast cancer) (2019)

Autologous hematopoietic stem cell transplantation for SPS spectrum disorder (2020)

Antibody-related movement disorders (2020)

Video: SCIg therapy (subcutaneous immunoglobulin replacement therapy) (2014)

UPDATE: Autologous haematopoietic stem cell transplantation in SPS: The UK experience (2020)

Autologous haematopoietic stem cell transplantation in SPS: The UK experience (2019)

Cannabis provides symptom relief in patient with treatment-resistant SPS (2019)

Anti-glutamate dehydrogenase antibody positive cerebellar ataxia and SPS responding to dual treatment with steroids and Intravenous Immunoglobulin. (2019)

VIDEO: HSCT for SPS (2019). Go to time stamp 42mins 44 secs

VIDEO: What is plasmapheresis? (2016)

PERM: Glycine receptor autoantibodies disrupt inhibitory neurotransmission (2019)

VIDEO: Intrathecal pump implantation (2014)

New thinking on SPS or syndromes (2019)

Video: How a baclofen pump Works (2014)

VIDEO: Understanding Immunoglobulin therapy (2017)

Plasmapheresis: What to expect (2017)

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Immunological basis for treatment of SPS (2010)

Anaesthesia and SPS (2017)

Childhood SPS Improved with rituximab (2012)

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SPS treatment using combined spinal epidural anaesthesia (2010)

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Finding the right medication

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Further childhood SPS Improved with rituximab (2012)

Rigidity and spasms in SPS (2006)

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