According to NORD, the National Organisation for Rare Disorders, there are five types of Stiff Person Syndrome:

1) Classic SPS

2) Focal SPS

3) Jerking SPS

4) Progressive Encephalomyelitis with Rigidity and Myoclonus (PERM)

5) Paraneoplastic-Related SPS

Click on the links below to take you to various SPS pages from the internet. They are strictly for information only and do not represent advice or recommendations by the UK and Ireland SPS Support Group and Charity. If you have more links you believe would be of interest to the community, please submit for consideration to:

Available or Suggested Treatments

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NICE is the UK's National Health Service (NHS) National Institute for Health and Care Excellence. This link takes you direct to NICE's website


This US government site brings together SPS and SPS-related links across the internet. The usagov link (LEFT) goes directly to the site section about SPS and is pre-loaded with a search for anything Stiff Person Syndrome. In the first 30 pages, there are 600 randomly arranged links, not all of which are SPS related/connected. Many, but not all, links are the same listed here on our website. However, refined searches can be carried out to reveal specific information/results.

Antibody-related movement disorders (2020)

Autologous haematopoietic stem cell transplantation in SPS: The UK Experience (2019)

Surgical treatment for toe deformities in SPS (2020)

Video: SCIg Therapy (Subcutaneous Immunoglobulin Replacement Therapy) (2014)

Clinicopathologic Features of Amphiphysin-IgG Autoimmune Neuropathy (first reported in stiff-person syndrome with breast cancer) (2019)

Anti-glutamate Dehydrogenase Antibody Positive Cerebellar Ataxia and Stiff Person Syndrome Responding to Dual Treatment with Steroids and Intravenous Immunoglobulin: A Case Presentation and Literature Review (2019)

Anaesthesia recommendations for SPS patients (2014)

Video: Intrathecal pump implantation (2014)

What is plasmapheresis? (2016)

HSCT for SPS (2019). Go to time stamp 42mins 44 secs

New thinking on SPS or syndromes (2019)

Anaesthesia and SPS (2017)

UPDATE: Autologous haematopoietic stem cell transplantation in SPS: The UK Experience (2020)

Cannabis Provides Symptom Relief in Patient with Treatment-Resistant SPS (2019)

PERM: Glycine receptor autoantibodies disrupt inhibitory neurotransmission (2019)

Video: How a Baclofen Pump Works (2014)

Plasmapheresis: What to expect (2017)

Understanding Immunoglobulin therapy (2017)

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Immunological basis for treatment of SPS (2010)

Childhood SPS Improved with rituximab (2012)

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SPS treatment using combined spinal epidural anaesthesia (2010)

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Finding the right medication

Further childhood SPS Improved with rituximab (2012)

Rigidity and spasms in SPS (2006)

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Copyright © 2018 Stiff Man Syndrome Charity. All rights reserved

UK Telephone: 01482 868881  

Stiff Man Syndrome UK and Ireland Support Group and Charity: Founded in 1998 by Liz Blows

Stiff Man Syndrome Support Group and Charity: Liz Blows (Chair), 75 Normandy Avenue, Beverley, East Yorkshire, HU17 8PF
Stiff Man Syndrome Support Group and Charity is not-for-profit
Charity Number: 1099206

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